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The Bioinformatics, Molecular Dynamics and Modeling (BiMoDyM) activity is dedicated to cutting-edge interdisciplinary research in computational biology, an emerging scientific discipline that is revolutionizing biology and medicine.
Through the interdisciplinary collaborations between academic disciplines (physics, mathematics, biology) and clinical research, BiMoDyM is working to establish structural and dynamical principles governing complex biological processes, allosteric regulation, and resistance mechanisms.
Combining classical modeling and molecular dynamics simulations methods with creating new theoretical, algorithmic, and software advances for analysing and visualizing of molecular dynamics, BiMoDyM, together with mathematicians and clinicians, generates new hypotheses that explain biological mechanisms in unpredictable previously ways. This scientific cross-fertilization is enriching both fields and will continue to do so in the coming decade.
Inspired by the milestone concept based on the coupling of the information induced by a local perturbation (effector), we proposed in 2011 the MOdular NETwork Analysis (MONETA), a new method designed to localize the perturbation propagation throughout a protein structure (Laine et al. 2011; Allain et al. 2014].